Building the Ultimate Glucose Disposal Agent

Whether you’re looking to reduce blood glucose, increase insulin sensitivity, or even allow for greater nutrient partitioning – these three factors will allow for one to grow while keeping fat gain to a minimum, assuming proper diet and nutrition are set in place.

Na-R-ALA

Clinical trials showing alpha lipoic acid may increase insulin sensitivity and reduce blood sugar
Improvements in GLUT-4 and PGC-1a have been identified following oral ingestion of ALA
Doses of 300-600mg up to twice per day prior to a carbohydrate meal

Acetyl-L-Carnitine (ALCAR)

Studies showing up to a 2 gram dose can increase the glucose disposal rate
10 days with a 2 gram ALCAR dose has been shown to increase insulin sensitivity
Doses of up to 2 grams either taken in a bolus or split into two 1 gram doses prior to a carbohydrate meal

The increase in muscular uptake of glucose is through the stimulation of AMPK. Mechanisms of increasing insulin sensitivity have been shown by shuttling the acyl and acetyl group into plasma, where it is to be excreted in the urine.

Agmatine

Ability to reduce blood glucose associated with an increase in beta-endorphin, which is known to increase tissue glucose uptake into skeletal muscle
Shown to have nutrient partitioning effects via GLUT4 mRNA upregulation
Doses of up to 2 grams split into multiple doses of 500-1000 mg doses prior to carbohydrate meals

Other compounds shown to have the ability to either increase insulin sensitivity, reduce blood glucose, and/or have nutrient partitioning effects:

4-hydroxyisoleucine

Shown to increase insulin sensitivity and glucose uptake in muscle cells, doing so by triggering translocation of GLUT4 receptors through the PI3-kinase/AKT pathway
Doses of up to 75-150 mg taken two to three times per day prior to carbohydrate meals

Banaba (Corosolic Acid)

Ability decrease serum blood sugar after carbohydrate ingestion by enhancing glucose uptake at the muscle cell
Significantly increasing insulin sensitivity and translocation of GLUT4 receptors
Doses of up to 150 mg taken two to three times per day prior to carbohydrate meals

Berberine

Ability to increase insulin sensitivity and reduce blood glucose via activation of AMPK leading to then inhibiting mitochondrial function, followed by clearing the extra AMPK to then enhancing mitochondrial function.
Doses of up to 500 mg taken two to three times per day prior to carbohydrate meals