Supplement Spotlight: Iron Forged Nutrition Contraband Black
Iron Forged Nutrition Contraband Black Series Product Highlights
Intense Skin Splitting Pump
Surge of Energy and Focus
Increased Endurance and Delayed Fatigue
Enhanced Mood and Drive
Beta-O [Orotic Acid]
Maxxendure-XT (stearoyl vannylimide]
L-Citrulline Malate 2:1
Product Write Up
Beta-O- [Orotic Acid]
Also known as pyrimidinecarboxylic acid, orotic acid is an intermediate in pyrimidine synthesis, which is required for DNA and RNA synthesis. It is naturally occurring in the diet; particularly in cow, goat, and sheep’s milk. Orotic acid is ultimately converted to beta alanine, which can subsequently be incorporated in anserine and carnosine. Orotic acid enhances pyrimidine pools. The body stores pools of pyrimidines and purines (such as ATP, GTP, CTP and UTP) and for use as energy sources, in cell signalling, and to participate in enzymatic reactions, and these pools can be taxed by intense and/or repeated exercise. Supplemental orotic acid may serve to replenish depleted pyrimidine pools. Orotic acid may be nootropic As a precursor of uridine monophosphate, orotic acid represents a source of bioavailable uridine. Although uridine is present in the diet, it is mainly in the form of RNA and not bioavailable. Several studies show nootropic effects of uridine, often in combination with choline and/or DHA. Orotic acid increases glycogen synthesis in muscle. Orotic acid is also precursor of uridine triphosphate (UTP). UTP is converted by the enzyme UDP–glucose pyrophosphorylase to uridine diphosphate glucose (UDPG). Glycogen synthase then combines the glucose residues from UDPG into long chains of glycogen; the remaining UDP molecules can then be recycled back into the process. Skeletal muscle uses glycogen as a fuel source during strenuous and prolonged exercise. Experiments from the 1970s demonstrated that additional uridine increased the rate of glycogen synthesis and thus that glycogen synthase was not the only rate-limiting step in the process. Beta alanine is a product of the catabolism of uracil, a metabolite of uridine, of which orotic acid is a precursor. This process isn’t instant, but begins within minutes of absorption. Orotic acid administration may therefore be viable alternative to beta-alanine to avoid the paresthesia ‘pins-and-needles’ side effect associated with large doses beta alanine.
Maxxendure-XT (stearoyl vannylimide]
TRPV1 activation stimulates the release of catecholamines such as adrenaline and noradrenaline from the adrenal medulla. Noradrenaline is a major regulator of brown fat activation, through β3 adrenoreceptor activation. Nonpungent capsaicin analogs have been demonstrated to activate brown adipose tissue and increase energy expenditure in a human clinical trial. A systematic review of human clinical trials observed that regular consumption of capsaicinoids increased energy expenditure, and significantly reduced abdominal adipose tissue levels. Chronic TRPV1 activation by dietary TRPV1 agonists can increase phosphorylated levels of protein kinase A (PKA) and endothelial NO synthase (eNOS), causing peripheral vasodilation and a decrease in blood pressure in hypertensive rats. The oral administration of TRPV1 agonists prevents adipogenesis and obesity in mice fed a high-fat diet. Stearoyl vanillylamide increased lipolysis and oxidation of free fatty acids in rats, resulting in increased capacity for exercise Some non-pungent capsinoids have also been found to activate TRPA1, another receptor that may be involved in cold detection.
L-Citrulline Malate 2:1
L-citrulline is classified as a non-essential a-amino acid and as such is not traditionally incorporated into proteins L-citrulline is produced in the body through two main pathways: it is synthesised from glutamine by the cells lining the small and via the conversion of L-arginine to nitric oxide. Citrulline does not have any direct role in fat metabolism so there is no basis to make any claims for fat loss associated with supplemental citrulline. Theoretically, citrulline may positively affect fat metabolism by increasing nitric oxide.
Taurine has several critical functions and can act similarly to creatine in that it expands your cells by helping the muscle cell itself hold more water, increasing cell volume. this is significant as expanded muscle cells boost hydration resulting in improved protein synthesis. This increased fullness in the appearance of muscle would be appreciated by bodybuilders. It is also believed that taurine enhances a lifter’s leverage, thus helping the lifter in handling heavier weights. Taurine is also effective as a cellular protector against exercise induced DNA damage. It appears to reduce muscle damage caused by exercise, therefore accelerating recovery between workouts. Research also indicates that taurine can improve exercise performance by increasing muscle force and contraction. Taurine can also exert an insulin-like effect. Research suggests that it can improve insulin resistance and help the body better use glucose.
In physiological trials, glucuronolactone has been shown to inhibit the synthesis of toxic by-products of intensive exercise as well as other negative effects causing fatigue. Various studies have investigated products containing glucuronolactone on physical performance. When human subjects were given an energy drink containing a combination of glucuronolactone, caffeine, and taurine, it was found that they experienced improvements in aerobic and anaerobic performance compared to those receiving a control. When used in a pre workout supplement, glucuronolactone in combination with the aforementioned ingredients resulted in an increase in total repetitions performed. This also led to an increase in an anabolic response among supplemented people. These results were later reproduced and supported by the same group of researchers . Such results suggest that glucuronolactone may help to increase strength and lean gains when used in conjunction with weight training.
Once ingested and absorbed, tyrosine is either: absorbed into the tissues and incorporated into proteins and peptides; used as precursors in smaller amounts for thyroxin, melanin, and neurotransmitter synthesis; or metabolised to glucose to be used for energy production. The catecholamines are involved in basic nervous system activities such as movement, memory, attention, problem solving, desire, motivation, “fight or flight” response, heart rate and stroke volume.
Cognition and Mental Performance. Moderate doses of caffeine have the ability to improve cognitive and mental performance by increasing alertness, attention and concentration5. The ability for increased focused is a definite benefit for a wide variety of sports, but is also important in the gym for focusing on your workout to ensure maximum effect. Poor attention can lead to increased risk of injury and decreased effectiveness of the exercises from poor form and posture during workouts. Endurance Capacity. Many of the studies relating to caffeine and exercise performance have looked at endurance performance. Many theories have been proposed over the exact way in which caffeine is able to increase endurance capacity, two of which have stood out in recent years. The first proposed mechanism is caffeine’s ability to reduce ratings of perceived exertion (RPE). RPE is a rating of how hard we believe an exercise to be at a single moment. Reductions in RPE then can prove beneficial to help us perform the exercise for longer; ie squeezing out that extra set or rep during a workout. The second proposed mechanism is caffeine’s ability to increase availability of fatty acids circulating in the blood which can help shift energy metabolism to use of fats rather than glycogen, which can be used later as a more immediate source of energy. Power and Strength. Unfortunately, not as many studies have been performed on effects of caffeine on short bursts of high intensity activity such as resistance exercise. A detailed review of several studies showed that caffeine ingestion is also able to positively affect strength and power production. Results ranged from increased number of repetitions performed, increased force production and increased amount of weight lifted.
Agmatine has been used for awhile now in the bodybuilding community as a supplement to help in the quest for increased muscle mass. While Agmatine itself has not been shown to impact muscle mass growth directly, it does offer several benefits which can help in achieving more muscle mass. As a potential strong neurotransmitter, it can improve the mind-muscle connection to improve the contractive efforts of our muscles. Stronger, more directed contractions can help promote improved effectiveness of exercises. Agmatine has also been shown to support release of luteinizing hormone releasing hormone or gonadotropin releasing hormone which is responsible for increasing luteinzing hormone levels. Luteinizing hormone stimulates male Leydig cells to produce testosterone. In addition, the pain reducing effects of Agmatine can not only be helpful in chronic pain conditions limiting exercise, but may also improve the endurance capacity as pain can often be a limiting factor to performance. Agmatine’s possible ability to regulate insulin production and increase the uptake of glucose may offer benefits for glycogen storage as well as a downgrade in the amount of glucose being transformed into fat.
Also known as theobromide and xantheose is a naturally occurring alkaloid that is a close chemical relative of caffeine. In the world of bodybuilding, it could help to improve workout intensity as well as being a natural diuretic. In some respects, theobromine has similar effects to that of caffeine. However, it does not stimulate the nervous system to the same degree. Instead, it is effective in being able to dilate blood vessels. Consequently, it has been used by doctors to treat diseases such as hypertension. Some studies have found that cocoa has an effect on increasing nitric oxide (NO) synthesis within the body. Some authors tend to attribute this to the flavone components of the cocoa. However, others experts have stressed that this may actually be an effect of theobromine. This means that theobromine may be effective in the increase of NO and hence give better pump if ingested pre workout.
Amentoflavone is an alkaloid with a huge number of benefits, which first came to the attention of the scientific community when it was discovered that it possessed anti-inflammatory properties. Further research indicated that Amentoflavone also has anti-viral properties, and has been shown to inhibit various cancers via a number of different methods. One of these methods is the inhibition of an enzyme based protein in the body called fatty acid synthase. Fatty acid synthase inhibition not only inhibits the growth of breast cancer cells but also prevents the replication of some viruses, and may stop the body from storing excess energy as fat and there is some evidence that amentoflavone can increase lipolysis, or fat breakdown . Amentoflavone is also a vasodilator, relaxing the blood vessels to allow greater blood flow. It also increases the strength of muscle contraction by increasing the release of calcium from muscle cells.Due to its interaction with the GABA and adrenal receptors, amentoflavone can boost mood and reduced feelings of anxiety, and it may act as a central nervous system stimulant.
IFN Contraband Black Series is available at TGBSupplements.com.
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